The results, presented in Science Advances, revealed additional nanobodies that in cell cultures and mice effectively cross-neutralized both the founder and beta variant of SARS-CoV-2 and even neutralized the more distantly related SARS-CoV-1.

“These nanobodies represent promising therapeutic candidates against several SARS-CoV-2 variants,” says first author Leo Hanke, a postdoctoral researcher who established the nanobody technology in the McInerney group.

The researchers are currently applying the same techniques to identify which nanobodies from this set are best able to neutralize omicron, the now dominating SARS-CoV-2 variant.

“Once established, these libraries can be expanded and mined for nanobodies that neutralize new emerging variants,” says Assistant Professor Ben Murrell, also joint senior author of both studies
— Read on phys.org/news/2022-03-potent-alpaca-nanobodies-neutralize-sars-cov-.html